Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Aug 17;8:998. doi: 10.3389/fimmu.2017.00998

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2017 Xu, Zhou, Lam and Pang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Target lysis by natural killer (NK) cells directly affected cell deaths in adjacent microwell connected by microchannel. (A) MCF7 cells had high tendency to die in pairs in 2–50 μm × 50 μm connected microwells. Microwell pairs outlined by red frame had MCF7 cells successfully seeded in both sides; microwells outlined by white frame had at least one target lysis; no target death is observed in remaining microwells. (B) Time sequence of MCF7 cells being attacked in connected microwells. First kill in 50 μm × 50 μm microwell happened after consecutive target cell lysis in 100 μm × 100 μm microwell. (C) Target cell death in microwell increased NK cell cytotoxicity in connected microwell. Y-axis is MCF7 cell death ratio D and NK cell killing efficiency E in 50 μm × 50 μm microwells; X-axis is number of target lysis in adjacent larger microwell.