Table 2.
List of top up-regulated DEGs in Hom-CKO vs. Het-CKO and their temporal changes within each genotype.
| Hom-CKO/Het-CKO* | 3-Week/2-Week§ | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2-Week | 3-Week | Control | Het-CKO | Hom-CKO | |||||||||
| No. | ACCN# | Gene | Description | Folds | p | Folds | p | Folds | p | Folds | p | Folds | p |
| 1 | NM_153744.1 | Prkag3 | protein kinase, AMP-activated, gamma 3 non-catatlytic subunit | 2.44 | 0.006 | 4.16 | 0.010 | 1.20 | NS | 1.01 | NS | 1.72 | NS |
| 2 | NM_173385.1 | Cilp | cartilage intermediate layer protein, nucleotide pyrophosphohydrolase | 2.44 | 0.013 | 4.18 | 0.020 | 0.63 | NS | 0.82 | NS | 1.41 | NS |
| 3 | BQ176278.1 | Grm1 | Glutamate Receptor,metabotropic 1 | 2.44 | 0.009 | 2.38 | 0.030 | 1.66 | NS | 1.74 | NS | 1.70 | NS |
| 4 | NM_183294.1 | Cdkl1 | cyclin-dependent kinase-like 1 (CDC2-related kinase) | 2.43 | 0.007 | 3.98 | 0.005 | 1.00 | NS | 0.88 | NS | 1.44 | 0.031 |
| 5 | BC052064.1 | Parp6 | Poly (ADP-ribose)polymerase family, member 6 | 2.39 | 0.002 | 3.72 | 0.007 | 1.09 | NS | 1.13 | NS | 1.76 | 0.026 |
| 6 | BI412344.1 | Mettl21d | Methyltransferase like 21D | 2.37 | 0.005 | 3.05 | 0.030 | 1.02 | NS | 1.34 | NS | 1.72 | 0.031 |
| 7 | NM_021467.4 | Tnni1 | troponin I, skeletal, slow 1 | 2.31 | 0.022 | 1.53 | NA | 0.11 | NS | 0.36 | NS | 0.24 | 0.043 |
| 8 | NM_007669.2 | Cdkn1a | cyclin-dependent kinase inhibitor 1A (P21) | 2.27 | 0.007 | 6.34 | 0.005 | 0.87 | NS | 1.25 | NS | 3.50 | 0.025 |
| 9 | NM_019875.1 | Abcb9 | ATP-binding cassette, sub-family B (MDR/TAP), member 9 | 2.25 | 0.004 | 3.61 | 0.030 | 1.11 | NS | 0.93 | NS | 1.49 | 0.046 |
| 10 | NM_016867.1 | Semcap2 | semaF cytoplasmic domain associated protein 2 | 2.22 | 0.007 | 4.87 | 0.007 | 1.21 | NS | 1.42 | 0.044 | 3.11 | 0.027 |
| 11 | NM_013468.2 | Ankrd1 | ankyrin repeat domain 1 (cardiac muscle) | 3.53 | 0.119 | 7.57 | 0.011 | 1.45 | NS | 1.06 | NS | 2.28 | NS |
| 12 | NM_013681.1 | Syn2 | synapsin II | 4.22 | 0.520 | 7.38 | 0.010 | 1.50 | NS | 1.12 | NS | 1.96 | NS |
| 13 | NM_019687.2 | Slc22a4 | solute carrier family 22 (organic cation transporter), member 4 | 1.42 | NA | 6.48 | 0.013 | 3.37 | NS | 0.83 | NS | 3.77 | 0.016 |
| 14 | CB848957.1 | Auh | AU RNA binding protein/enoyl CoA hydratase | 1.78 | NA | 6.25 | 0.004 | 1.03 | NS | 0.94 | NS | 3.31 | 0.014 |
| 15 | AI853801.1 | Srsf1 | Serine-arginine-rich splicing factor 1 | 2.78 | NA | 6.21 | 0.002 | 1.25 | NS | 1.44 | NS | 3.23 | 0.015 |
| 16 | NM_010077.1 | Drd2 | dopamine receptor 2 | 1.61 | NA | 6.05 | 0.012 | 1.22 | NS | 1.07 | NS | 4.01 | 0.041 |
| 17 | AA536960.1 | Rexo1 | RNA exonuclease 1 homolog | 1.10 | NA | 5.79 | 0.008 | 1.22 | NS | 1.08 | NS | 5.68 | 0.028 |
| 18 | BC027359.1 | Mphosph8 | M phase phosphoprotein 8 | 2.72 | 0.002 | 5.45 | 0.008 | 0.76 | NS | 0.77 | NS | 1.54 | NS |
| 19 | NM_011103.1 | Prkcd | protein kinase C, delta | 2.92 | 0.001 | 5.40 | 0.004 | 1.19 | NS | 1.11 | NS | 2.06 | 0.017 |
| 20 | W83574.1 | Ndufa3 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3 | 2.59 | 0.002 | 5.23 | 0.014 | 0.89 | NS | 0.94 | NS | 1.89 | 0.014 |
| 21 | NM_011485.3 | Star | steroidogenic acute regulatory protein | 1.68 | NA | 5.15 | 0.030 | 1.16 | NS | 0.83 | NS | 2.56 | NS |
| 22 | NM_145495.1 | Rin1 | Ras and Rab interactor 1 | 2.03 | NA | 4.96 | 0.005 | 1.46 | NS | 1.07 | NS | 2.60 | 0.026 |
| 23 | NM_007474.1 | Aqp8 | aquaporin 8 | 2.07 | NA | 4.81 | 0.030 | 1.12 | NS | 1.14 | NS | 2.66 | NS |
| 24 | NM_199222.1 | Lman1l | Lectin, mannose-binding 1 like | 1.42 | NA | 4.77 | 0.013 | 1.24 | NS | 1.16 | NS | 3.88 | 0.013 |
| 25 | AI647986.1 | Bhmt2 | Betaine-homocysteine methyltransferase 2 | 2.72 | 0.004 | 4.60 | 0.006 | 0.91 | NS | 1.15 | NS | 1.94 | 0.044 |
| 26 | BY457927.1 | Rps3a1 | Ribosomal protein S3a | 1.21 | NA | 4.52 | 0.008 | 1.04 | NS | 1.12 | NS | 4.17 | 0.016 |
| 27 | AK009352.1 | Nmrk2 | Nicotinamide riboside kinase 2 | 2.46 | 0.017 | 4.39 | 0.028 | 1.08 | NS | 1.25 | NS | 2.24 | NS |
| 28 | NM_080640.3 | Baalc | brain and acute leukemia, cytoplasmic | 1.22 | NA | 4.38 | 0.030 | 1.15 | NS | 1.08 | NS | 3.87 | 0.037 |
| 29 | NM_024286.1 | Popdc3 | popeye domain containing 3 | 1.91 | NA | 4.28 | 0.005 | 1.41 | NS | 1.00 | NS | 2.23 | 0.025 |
| 30 | BE911434.1 | Fam20a | Family with sequence similarity 20, member A | 1.41 | NA | 4.23 | 0.003 | 1.00 | NS | 0.98 | NS | 2.93 | 0.019 |