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. 2017 Aug 18;7:8738. doi: 10.1038/s41598-017-09315-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Venn diagrams of different methods and their assessments for the test set. The inner three circles compare the methods when at least one method correctly predicted the treatment outcome for a pre- and post-treatment pair. The outer circle contains the pre- and post-treatment pairs for which all three methods incorrectly predicted the treatment outcome. (a) The three computer methods correctly predicted the same outcome of the patients for 39% (21/54) of the pre- and post-treatment pairs. (b,c) The two radiologists correctly agreed on the outcome of 43% of the cases ((18 + 5)/54 for (b) and (17 + 6)/54 for (c)). (d,e) Radiologists 1 correctly agreed with the DL-CNN and the RF-SL methods for 19 and 20 cases, respectively, while Radiologist 2 correctly agreed with the DL-CNN and the RF-SL methods for 24 and 21 cases, respectively.