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. 2017 Aug 18;7:8717. doi: 10.1038/s41598-017-08969-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Illustration of a pair of corresponding in vivo prostate MRI (c) and ex vivo histology images (b). On panel (a) one can observe the cancer annotations made by two radiologists (green and red) unblinded to the corresponding histology images. The divergent annotations made by the two radiology readers, in spite of having access to the pathology images, suggests the need for accurate co-registration of pathology and radiology imaging in order to ascertain the ground truth extent for disease on radiology imaging ((d) the overlap registration visualization).