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. 2017 Aug 18;7:8717. doi: 10.1038/s41598-017-08969-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Illustration of a frequency plot showing in how many instances either SSERg or MSERg registration yielded the best registration result. We compared 8 different SSERg combinations along with MSERg on the same 25 clinical and synthetic testing cases. (a) Shows the frequency of each registration method having the greatest Tumor DSC within the clinical testing set. (b) and (c) illustrate the frequency of each registration method with the least mean deformation difference (MDD), in case of T1 to PD and T2 to PD registration respectively. Compared to SSERg, MSERg has more accurate and robust registration performance across different datasets.