Table 1.

General features of C57 and Ctsk ^−/− mice following 4-weeks of STZ-treatment.

Parameter	WT	WT-STZ	Ctsk −/−	Ctsk −/− –STZ
Body weight (g)	27.1 ± 0.8	22.7 ± 1.4*	25.9 ± 0.9	24.7 ± 0.8
Body weight gain (g)	1.67 ± 0.46	−2.44 ± 0.62*	1.29 ± 0.26	−0.66 ± 0.44*†
White adipose tissue (g)	1.37 ± 0.09	014 ± 0.06*	0.36 ± 0.03	−0.20 ± 0.04
Heart weight (mg)	131 ± 5	117 ± 8	128 ± 9	125 ± 5
Liver weight (g)	1.39 ± 0.07	1.43 ± 0.08	1.37 ± 0.09	1.53 ± 0.06
Kidney weight (g)	0.32 ± 0.02	0.33 ± 0.02	0.36 ± 0.03	0.38 ± 0.01
Heart/body weight (mg/g)	4.73 ± 0.11	5.21 ± 0.14	4.79 ± 0.21	4.88 ± 0.15
Liver/body weight (mg/g)	50.4 ± 1.3	64.1 ± 1.4*	51.4 ± 1.6	60.1 ± 2.7*
Kidney/body weight (mg/g)	11.5 ± 0.5	14.9 ± 0.8*	13.4 ± 0.5	15.0 ± 0.5*
Fasting blood glucose (mg/dL)	107 ± 8.5	415 ± 55*	110 ± 7.4	287 ± 32*†
Water consumption (mL)	5.4 ± 0.25	16.2 ± 2.5*	5.6 ± 0.97	19.7 ± 2.6*
Cardiac GSH (nmol/mg tissue)	26.9 ± 1.7	24.7 ± 1.1	26.6 ± 1.8	29.9 ± 1.4
Cardiac GSSG (nmol/mg tissue)	14.3 ± 0.9	19.6 ± 0.7*	13.3 ± 1.1	17.2 ± 0.8
Cardiac GSH/GSSG ratio	1.95 ± 0.16	1.28 ± 0.07*	2.08 ± 0.11	1.80 ± 0.15†

Mean ± SEM, n = 6 to 8 mice per group. ^*p < 0.05 versus WT group; ^†p < 0.05 versus WT-STZ group.