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. 2017 Aug 18;7:8776. doi: 10.1038/s41598-017-07141-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Post-translational tyrosine sulfation reaction catalysed by TPST. (a) The tyrosine residue of a substrate protein is sulfated by TPST using the donor substrate, PAPS. (b) The amino-acid sequences of the substrate peptides used in this study. C4P5Y3 corresponds to an nine-amino-acid region encompassing the tyrosine sulfation site Y741 of human complement C4. Two Tyr residues (Y738 and Y743) in the original sequences have been mutated to Phe and only one Tyr (Y741) residue exists in the peptide. C4P5Y5 corresponds to an eleven-amino-acid region encompassing the tyrosine sulfation site Y741 of human complement C4. Two Tyr residues (Y738 and Y743) in the original sequences have been mutated to Phe and only one Tyr (Y741) residue exists in the peptide. The gastrin peptide corresponds to a twelve-amino-acid region encompassing the tyrosine sulfation site Y87 of human gastrin.