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. 2017 Aug 18;7:8776. doi: 10.1038/s41598-017-07141-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Three substrate peptides in the active site of human TPST1. (a–c) The electron density maps showing the image of C4P5Y5 and the gastrin peptide (simulated annealed omit Fo–Fc maps contoured at 2.5 σ and 1.7 σ, respectively). The Fo–Fc maps are drawn in olive. (a) Fo–Fc map of C4P5Y5. (b) Fo–Fc map of the gastrin peptide productive form. (c) Fo–Fc map of the gastrin peptide nonproductive form. (d–f) Interaction of Y⁰ and the residue at the subsite -1 in substrate peptides with human TPST1. Hydrogen bonds are depicted as orange dotted lines. The main chain and side chain of Y⁰ and the residue at the subsite -1 in the substrate peptide are shown. Only the main chain of the other residues in the substrate peptide is shown. Each amino acid sequence is respectively shown below. (d) Human TPST1-PAP-C4P5Y5. (e) The human TPST1-PAP-gastrin peptide productive form. (f) The human TPST1-PAP-gastrin peptide nonproductive form. (g–i) Close-up views of the binding site of C4P5Y5 and the gastrin peptide by surface representation. (g) Human TPST1-PAP-C4P5Y5. (h) The human TPST1-PAP-gastrin peptide productive form. (i) The human TPST1-PAP-gastrin peptide nonproductive form.