Table 2. Phenotypic comparison of wild-type and Pcsk9^-/- mice fed 0.2% lovastatin.

	WT		Pcsk9
Parameter	Chow	0.2% lov.	Chow	0.2% lov.
No. of mice	12	12	12	12
Body weight, g	24.4 ± 1.0	26.4 ± 1.2	25.8 ± 1.0	24.7 ± 0.7
Plasma cholesterol, mg/dl	80.9 ± 5.1	71.1 ± 3.0	51.4 ± 2.3*	40.8 ± 1.8*,**
Plasma TG, mg/dl	94.4 ± 8.7	64.5 ± 4.6*	100 ± 5.9	66.2 ± 4.2*,**

Mean values of pooled data from three independent experiments. The eight male and four female mice (12-14 weeks of age) in each group were fed a standard rodent chow or the standard chow supplemented with 0.2% (wt/wt) lovastatin (lov.) for 7 days. The mice were killed nonfasted. Each value represents the mean ± SEM. *, A statistical difference of P < 0.01 (Student's t test) between the indicated group and WT mice fed chow. **, A statistical difference of P < 0.01 (Student's t test) between Pcsk9^-/- mice fed 0.2% lovastatin and chow.