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. 2017 Aug 18;7:8725. doi: 10.1038/s41598-017-08975-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Increased number of megakaryocytes in adult bone marrow and embryonic liver. Representative micrographs of May-Grünwald Giemsa stained bone marrow megakaryocytes from WT and Epac1^−/− mice. (B) Flow cytometric determination of bone marrow megakaryocytes numbers in Epac1^−/− (n = 9) and WT (n = 10) mice. (C) Flow cytometric scatter plots with the gating strategy used to obtain data in B are shown. (D) Toluidine-stained sections of mouse embryonic livers showing megakaryocytes Arrowheads indicate demarcation membrane. (E) Number of megakaryocytes per mm² in livers from WT (n = 5) and Epac1^−/− (n = 7) embryos (E14). Data are average and + /− SEM. LN; lobulated nucleus, BMP; bone marrow population, NBMP; nucleated bone marrow population, MK; megakaryocytes. *P < 0.05, ***P < 0.005, Student’s t-test. The bars indicate 20 μm in A and D.