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. 2017 Aug 18;7:8725. doi: 10.1038/s41598-017-08975-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Epac1^−/− mice exhibit a delayed rate of clot formation and fragile clot stability ex vivo. ROTEM characterization of the coagulation process in citrated whole blood from WT and Epac1^−/− mice. Activated CT: clotting time i.e., the latency until the clot reaches a firmness of 2 mm, CFT: clot formation time and MCF: maximum clot firmness in mm was assessed by ROTEM assays (A) INTEM, (B) EXTEM and (C) FIBTEM. In FIBTEM assays the actin polymerization and platelet activation blocker cytochalasin D is present. Each point represents the measurements of one mouse. The horizontal dotted lines represent the median, n = 5–11 mice per group. *P < 0.05, **P < 0.01, Student’s t-test.