Table 2.
The impact of Epac1 deletion on expression of ILK and GPIb-related platelet adhesion proteins, detected by proteomics.
| Protein | Part of/associated with complex | Unique peptides | Intensity WT | Intensity Epac1−/− | Ratio KO/WT | PEP value |
|---|---|---|---|---|---|---|
| GPIbα | GPIb-IX-V | 5 | 9373800 | 9188200 | 0.98 | 2.21E-106 |
| GPIbβ | GPIb-IX-V | 2 | 7048600 | 919540 | 0.13 | 3.68E-72 |
| GPIX | GPIb-IX-V | 1 | 1253500 | n.f. | — | 0.0013581 |
| GPV | GPIb-IX-V | 6 | 5321700 | 16134000 | 3.03 | 1.57E-79 |
| ILK | Integrin αIIbβ3 | 5 | 1686400 | 6406100 | 3.80 | 2.73E-12 |
ILK, integrin linked protein kinase, GP, glycoprotein.