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. 2017 Aug 18;7:8780. doi: 10.1038/s41598-017-09310-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Changes of the retinal perfusion in response to increased IOP. (a) En-face OCTA maximum-intensity-projections of three plexuses at three different IOP levels. Non-perfused patches in the deeper retinal capillary plexus were observed at increased IOP levels of 75 mmHg. While the retinal perfusion stopped at an IOP level of 105 mmHg, some major choroidal vessels were still present in the OCTA images. (scale bar = 150 μm) (b) Quantitative analysis of the flux in all three plexuses in four animals. The flux in the superficial retinal plexus dropped significantly in the range of 65 to 95 mmHg while the flux in the deeper retinal capillary plexus earlier decreased significantly between 55 mmHg and 85 mmHg. (*significant difference: p < 0.05).