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. 2017 Aug 18;7:8780. doi: 10.1038/s41598-017-09310-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Model of the ocular perfusion pressure (OPP) and perfusion changes during IOP elevation. (a) An elevation of the IOP will cause a decrease in the mean OPP. (b) The pressure amplitude defined as the difference between the systolic and diastolic pressure level remains unchanged until the diastolic OPP undercuts the diastolic blood pressure. (c) The ocular perfusion will stop at this threshold and hence the fundus pulsations will vanish as well.