Table 5.
Combined and interactive effects between polymorphisms in CYP27B1 and dietary factors in CRC.
| Dietary factors | rs10877012 recessive model | Interaction | rs4646536 (recessive model) | Interaction | ||||
|---|---|---|---|---|---|---|---|---|
| TT + TG | GG | OR i (95% CI) | P | TT + TC | CC | |||
| OR gd (95% CI) | OR gd (95% CI) | OR i (95% CI) | P | |||||
| Cereals (g/week) | ||||||||
| <50 | 1.00 | 0.43 (0.23–0.79) | 1.76 (0.80–3.84) | 0.160 | 1.00 | 0.46 (0.25–0.85) | 1.77 (0.80–3.90) | 0.159 |
| ≥50 | 0.41 (0.319–0.55) | 0.31 (0.19–0.52) * | 0.40 (0.30–0.54) | 0.33 (0.20–0.54) | ||||
| Overnight meal (times/week) | ||||||||
| >3 | 1.00 | 0.44 (0.22–0.85) | 0.60 (0.27–1.34) | 0.211 | 1.00 | 0.49 (0.24–0.97) | 0.63 (0.28–1.45) | 0.281 |
| ≤3 | 0.62 (0.47–0.81) | 0.45 (0.28–0.73) | 0.64 (0.48–0.84) | 0.49 (0.30–0.78) | ||||
| Allium vegetable (time/week) | ||||||||
| <1 | 1.00 | 0.82 (0.42–1.60) | 0.62 (0.28–1.41) | 0.254 | 1.00 | 0.91 (0.45–1.83) | 0.60 (0.26–1.39) | 0.235 |
| ≥1 | 0.80 (0.59–1.08) | 0.40 (0.24–0.68) | 0.78 (0.57–1.06) | 0.43 (0.26–0.71) | ||||
| Pork (g/week) | ||||||||
| ≥250 | 1.00 | 0.68 (0.37–1.24) | 1.29 (0.59–2.82) | 0.531 | 1.00 | 0.63 (0.35–1.15) | 1.05 (0.48–2.29) | 0.910 |
| <250 | 0.64 (0.49–0.85) | 0.34 (0.20–0.57) | 0.64 (0.49–0.85) | 0.39 (0.23–0.65) | ||||
| Milk (time/week) | ||||||||
| ≤2 | 1.00 | 0.57 (0.35–0.93) | 1.19 (0.51–2.82) | 0.685 | 1.00 | 0.58 (0.35–0.95) | 1.34 (0.57–3.17) | 0.501 |
| >2 | 0.80 (0.59–1.09) | 0.54 (0.27–1.08) | 0.78 (0.57–1.06) | 0.61 (0.30–1.21) | ||||
| Vegetable (g/day) | ||||||||
| ≤250 | 1.00 | 0.54 (0.34–0.85) | 1.51 (0.66–3.50) | 0.332 | 1.00 | 0.56 (0.36–0.89) | 1.58 (0.69–3.65) | 0.279 |
| >250 | 1.15 (0.86–1.54) | 0.94 (0.48–1.87) | 1.13 (0.84–1.52) | 1.01 (0.51–1.98) | ||||
| Canned fruit | ||||||||
| Yes | 1.00 | 0.23 (0.04–1.34) | 0.33 (0.05–2.07) | 0.237 | 1.00 | 0.40 (0.07–2.21) | 0.57 (0.10–3.29) | 0.527 |
| No | 0.48 (0.28–0.81) | 0.32 (0.17–0.61) | 0.48 (0.28–0.82) | 0.34 (0.18–0.64) | ||||
| Braised fish (times/week) | ||||||||
| ≥1 | 1.00 | 0.43 (0.22–0.86) | 0.63 (0.28–1.45) | 0.278 | 1.00 | 0.40 (0.20–0.80) | 0.51 (0.22–1.17) | 0.112 |
| <1 | 0.50 (0.37–0.68) | 0.34 (0.21–0.57) | 0.48 (0.36–0.65) | 0.37 (0.23–0.62) | ||||
| Soybean (times/week) | ||||||||
| >1 | 1.00 | 0.62 (0.41–0.94) | 1.18 (0.44–3.17) | 0.740 | 1.00 | 0.66 (0.43–1.00) | 1.17 (0.43–3.18) | 0.755 |
| ≤1 | 0.81 (0.59–1.10) | 0.42 (0.18–1.01) | 0.82 (0.59–1.12) | 0.46 (0.19–1.10) | ||||
ORgd: ORgenetic&dietary, combined effects of polymorphisms and dietary factors. ORi: ORinteraction, interactive effects of polymorphisms and dietary factors.
Note, we analyzed the combined effects for nine dietary factors and four polymorphisms of CYP24A1 and CYP27B1, the P value after Bonferroni correction is 0.05/36 = 0.0014. We analyzed the interactive effects using logistic regression, the significant P value of interactive effect is 0.05.
*Bold values indicate significance after Bonferroni correction.