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. 2017 Aug 18;7:8855. doi: 10.1038/s41598-017-09592-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Redirecting biosynthetic fluxes towards specific compounds by engineering CYP76AH24 specificity. (A) Biosynthetic shift from carnosic acid to pisiferic acid production in yeast cells. (B) Abolishing undesirable production of 11-keto-miltiradiene and 11-hydroxy-ferruginol production in yeast to favor biosynthesis of salviol.