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. 2017 Aug 18;7:8830. doi: 10.1038/s41598-017-09311-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The change of weight in all three groups and swimming time in DS model group. The weight of all rats was measured weekly and the swimming time of the rats for the DS model group was measured every 2 days from the start to the end of the experiment. Rats in DS model group were weighed before exhaustive swimming. Data were reported as the mean ± standard deviation in each group. *P < 0.05, compared with the control group. The swimming time was calculated from the point when rats were placed in water to the point when 50% of the rats were exhaustively submerged in water for 10 s.