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. 2017 Aug 18;7:8830. doi: 10.1038/s41598-017-09311-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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H& E and Masson staining on kidney tissue of rats in control, disease and DS groups. H& E staining: rats in disease and DS groups were observed with renal cortex and medulla atrophied, glomerular sclerosis and atrophy, renal tubular expansion, structure diffusion, visible hyalinization, protein tube and a large number of cavity; Glomerular and capillary congestion and clear inflammatory cell infiltration was also observed. Masson staining: glomerular basement membrane and tubule interstitial fibers proliferated significantly in disease and DS groups of rats.