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. 2017 Apr 10;36(33):4673–4681. doi: 10.1038/onc.2017.60

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Copyright © 2017 The Author(s)

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Summary of the structure and functions of the ZNF281 protein. (a) Schematic presentation of the human ZNF281 protein. Boxes represent distinct functional domains of ZNF281. ZNF281 is a substrate of ATM/ATR DNA damage-activated kinases (yellow P circles) as well as CDKs (Cyclin-dependent kinases; orange P circle), however, the impact of ATM/ATR phosphorylation or CDK phosphorylation on ZNF281 function is unknown. (b) expression of ZNF281 is regulated by a variety of protein factors and miRNAs (shown in the upper part of panel b). ZNF281 (zfp281) can regulate positively or negatively a number of target genes (blue arrows in the lower part of panel b). ZNF281 and its murine homolog zfp281 are involved in the induction of epithelial–mesechymal transition (EMT) of colon cancer cells, in control of cellular stemness, in the imprinted expression of the Meg3 polycistron and in regulation of genes involved in the DNA-damage response (DDR). Transcription repression of Nanog and Tet2 is achieved through recruitment of the histone deacetylase HDAC2. Arrow-headed and bar-headed lines indicate activation and inhibition respectively.