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. 2017 Aug 18;7:8803. doi: 10.1038/s41598-017-09169-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ADAR1 and ADAR2 proteins are overexpressed in EC. Panel A. ADAR1 and ADAR2 expression in EC tumors (T) compared to the paired control (C) tissues. Relative protein expression of each enzyme is plotted in the bar graphs. Panel B. Example of ADAR1 and ADAR2 staining levels in a matched EC tissue with the corresponding paired control. Panel C. ADAR1 and ADAR2 expression in EC tissues significantly correlate with the tumor grade. Panel D. Example of ADAR1 and ADAR2 staining levels in a set of 3 different EC tumor grades slides (grade 1, 2 and 3). Panel E. ADAR1 and ADAR2 levels are significantly increased in NEEC compared to EEC tumors. Panel F. Example of ADARs staining in EEC and NEEC tumors.