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. 2017 Aug 18;7:8784. doi: 10.1038/s41598-017-07350-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Carbohydrate metabolism in enterocytes. (A) Schematic overview of carbohydrate absorption and secretion pathways in murine enterocytes (adapted from KEGG). Apical and basolateral location of GLUT2 has been included in the graph; (B) Simulated maximal glucose and fructose absorption and secretion rates modelled in the absence of apically located GLUT2; (C) Simulated maximal glucose and fructose absorption and secretion rates modelled in the presence of apically located GLUT2.