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. 2017 Aug 18;7:8708. doi: 10.1038/s41598-017-07812-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Hematoxylin and eosin staining and histopathological scores of Achilles tendons after an intratendinous injection of collagenase or only needle punctures. Control (a) and injured tendons at weeks 1 (b), 4 (c), and 8 (d). The summary of histopathological score (e). CR, calcified deposits; arrowhead, chondrocyte-like cells; arrow, vascular structure. The histopathological scores: *compared with the Control group; ⁺compared within the Collagenase group; ^*/⁺p < 0.05; ^**/⁺⁺p < 0.01; ^***/+++p < 0.001.