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. 2017 Aug 18;7:8861. doi: 10.1038/s41598-017-07567-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The effect of promysalin and the derivative analogs on S. thermophilus DSM 20617 ^T cell membrane integrity and cell viability. Flow cytometry density diagrams show the SYBR Green I vs PI fluorescence of cells exposed to promysalin or to the analogs 2–8 (100 µg/ml). Viable cells are gated in G1, viable cells with slightly damaged cell membrane are gated in G2. Dead cells with damaged membrane are gated in G3. The transition of cell population from gate G1 to gate G3 is related to the entity of cell membrane damage. The reduction of cell viability measured by standard plating was shown in parenthesis. The reduction of cell viability was calculated using as reference (100% of viability reduction) the bactericidal effect of chlorhexidine. The differences in structure between promysalin and the analogs are indicated by the red arrows. Flow cytometry density diagrams showing the SYBR Green I vs PI fluorescence of cells exposed to chlorhexidine or DMSO are shown in SI, Figure S5.