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. 2017 Aug 18;7:8770. doi: 10.1038/s41598-017-09395-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of pretreatment with B. pseudocatenulatum LI09 or B. catenulatum LI10 on the overall structural changes of gut microbial communities during D-GalN-induced acute liver injury. (a) The alpha diversity of the gut microbiome, determined by Simpson index and Chao1 index, in the LI09 or LI10 group was compared with that in the PC group. Values are expressed as the median with interquartile range. (b) The principal coordinate analysis (PCoA) plot shows the beta diversity of the gut microbiome with unweighted UniFrac distance derived from 16S-based sequencing data. Composition profiles of the caecal flora in the LI09 or LI10 group was compared with those in the PC and negative acute liver injury control (NC) groups.