Table 1.
Effects of pretreatment with five Bifidobacterium strains on liver function during D-GalN-induced acute liver injury.
| ALT (U/L) | AST (U/L) | GGT (U/L) | GPDA (U/L) | TBA (µmol/L) | TB (µmol/L) | ALB (g/L) | |
|---|---|---|---|---|---|---|---|
| LI06 (n = 9) | 5005.0 ± 4147.8** | 7505.0 ± 6705.4 | 10.9 ± 8.4* | 303.6 ± 161.9 | 261.6 ± 167.0* | 12.5 ± 10.3 | 37.2 ± 3.1 |
| LI07 (n = 9) | 6340.0 ± 5733.0 | 9135.0 ± 7725.8 | 14.6 ± 13.1 | 318.8 ± 203.9 | 284.6 ± 192.6 | 43.6 ± 83.7 | 36.7 ± 2.9 |
| LI08 (n = 9) | 6431.1 ± 2933.8* | 8200.0 ± 4038.7 | 13.2 ± 6.6* | 356.3 ± 135.3 | 326.0 ± 116.4* | 23.7 ± 12.5 | 36.8 ± 1.5 |
| LI09 (n = 9) | 4191.1 ± 2777.8*** | 5800.0 ± 3601.0** | 13.8 ± 11.4 | 272.4 ± 137.0** | 285.2 ± 136.9* | 17.4 ± 12.8 | 36.8 ± 1.7 |
| LI10 (n = 9) | 3888.9 ± 3190.7*** | 5471.1 ± 4247.0** | 10.8 ± 8.2* | 250.2 ± 151.0** | 274.6 ± 177.0* | 16.3 ± 12.5 | 37.1 ± 2.1 |
| PC (n = 8) | 10000.0 ± 2058.1 | 12050.0 ± 3342.2 | 21.5 ± 9.0 | 427.4 ± 56.3 | 440.1 ± 60.6 | 68.6 ± 88.0 | 34.5 ± 3.7 |
| NC (n = 6) | 49.5 ± 7.8*** | 101.2 ± 12.2*** | NA | 65.7 ± 14.1*** | 54.2 ± 24.3*** | 1.8 ± 0.4 | 37.3 ± 2.4 |
Values are expressed as the mean ± SD. The serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), glutamyltransferase (GGT), glycylproline dipeptidyl aminopeptidase (GPDA), total bile acid (TBA), total bilirubin (TB) and albumin (ALB) were determined after 24 h of D-galactosamine (D-GalN) administration. Compared with the PC group, *p < 0.05, **p < 0.01, ***p < 0.001.