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. 2017 Aug 18;7:8814. doi: 10.1038/s41598-017-06851-3

Figure 1.

Figure 1

Dose and time-dependent effects on cell proliferation by TMZ in U87 cells. (a) The cell viability in various concentrations (–•–, control (DMSO only); –○–, 12.5 μg/ml; –▼–, 25 μg/ml; –△–, 50 μg/ml; –■–, 100 μg/ml) of TMZ treated cells for different time frames: 0 day, 1 day, 2 days, 3 days, 4 days and 5 days. The data were means ± SD of four independent experiments. n = 3 (b) Morphology and cell density of U87 glioblastoma cell lines treated with or without vary concentration TMZ (0 μg/ml, control; 12.5 μg/ml; 25 μg/ml; 50 μg/ml; 100 μg/ml) for 0–4 days. Scale bar = 10 μm.