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. 2017 Aug 18;7:8814. doi: 10.1038/s41598-017-06851-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cell cycle and apoptosis-related genes expression in response to TMZ in human GBM cell lines. (a) Analysis of BNIP3, GADD45A and P21 gene expression pattern at fourth day after TMZ treatment in dose-dependent manner (0 μg/ml, control; 12.5 μg/ml; 25 μg/ml; 50 μg/ml; 100 μg/ml) by RT-PCR. (b) Analysis of BNIP3, GADD45A and P21 gene expression pattern at fourth day after TMZ treatment in dose-dependent manner (0 μg/ml, control; 12.5 μg/ml; 25 μg/ml; 50 μg/ml; 100 μg/ml) by western blotting. Full-length blot was shown in Supplementary Fig. 5. (d),(e) Analysis of the expression of GADD45A in U87, U373, TR-U373 and T98 cells at forth day after TMZ (25 μg/ml) treatment by RT-PCR. The bar graph shows the quantification of GADD45A gene expression level in U87 (c), U373 (d), T98 (e) and TR-U373 (f) cells. Full-length gels were shown in Supplementary Fig. 3. n = 3, *p < 0.05.