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. 2017 Aug 18;7:8814. doi: 10.1038/s41598-017-06851-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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TMZ induced apoptosis in U87, U373 and T98 cell lines with TMZ or GADD45A siRNA treatment. U87, U373 and T98 cells were pretreated with or without GADD45A siRNA before TMZ (25 μg/ml) or DMSO only treatment. The cell apoptosis was examined at day 4 after drug treatment by V-FITC/PI staining and flow cytometry analysis. (a) The dot plots shows the percentage of different apoptosis stage. FITC⁻/PI⁻, FITC⁺/PI⁻, FITC⁺/PI⁺, FITC⁻/PI⁺ was regarded as living, early apoptotic, late apoptotic and necrotic cells, respectively. The quantification of percentage of apoptotic (early + late apoptotic cells) and necrotic cells in U87 (b), U373 (c) and T98 (d). n = 3, *p < 0.05.