Table 1.

Cell cycle and apoptosis-related genes expression fold change in U87 GBM cells treated with TMZ.

Gene symbol	Acc. No.	Description	GO Term	Fold change
CDKN1A (p21)	NM_000389	Cyclin-dependent kinase inhibitor 1A (p21, Cip1)	Cell cycle	7.23
GADD45A	NM_001924	Growth arrest and DNA-damage-inducible, alpha	Cell cycle	2.21
TNFRSF10B	NM_003842	Tumor necrosis factor receptor superfamily, member 10b	Apoptosis	2.12
GADD45A	NM_001924	Growth arrest and DNA-damage-inducible, alpha	Apoptosis	1.98
TNFSF7	NM_001252	Tumor necrosis factor (ligand) superfamily, member 7	Apoptosis	1.49
CDK4	NM_000075	Cyclin-dependent kinase 4	Cell cycle	1.33
TNFRSF12A	NM_016639	Tumor necrosis factor receptor superfamily, member 12A	Apoptosis	1.3
PCNA	NM_182649	Proliferating cell nuclear antigen	Cell cycle	1.27
TNFRSF1B	NM_001066	Tumor necrosis factor receptor superfamily, member 1B	Apoptosis	1.26
CCNH	NM_001239	Cyclin H	Cell cycle	1.22
BNIP3	NM_004052	BCL2/adenovirus E1B 19 kDa interacting protein 3	Apoptosis	0.43
CDC20	NM_001255	CDC20 cell division cycle 20 homolog (S. cerevisiae)	Cell cycle	0.8
CUL1	NM_003592	Cullin 1	Cell cycle	0.84
BID	NM_001196	BH3 interacting domain death agonist	Apoptosis	0.85
TNFRSF1A	NM_001065	Tumor necrosis factor receptor superfamily, member 1A	Apoptosis	0.89

Data derived from GEArray^® Human cell cycle and apoptosis microarray by hybridizing cDNA synthesized from total mRNA derived from U87 cells treated with or without TMZ (25 μg/ml).