Fig. 1.

Autoregulation and neuroimaging results from a patient (patient 6: neonatal male) who was placed on VV ECMO for meconium aspiration secondary to PPHN. (a) Partial enlarged figure of WTC between the spontaneous fluctuations of MAP and ${\mathrm{S}}_{\mathrm{ct}}{\mathrm{O}}_2$. In this graph, the $x$-axis represents the time, the $y$-axis represents the wavelet scale (in inverse proportion to Fourier frequency), the color scale represents the squared cross-wavelet coherence ($R^2$) that ranges from 0 to 1, and the black line contours designate the areas of significant coherence ($p<0.05$) identified through Monte Carlo simulation. The arrows designate the relative phase between MAP and ${\mathrm{S}}_{\mathrm{ct}}{\mathrm{O}}_2$: a rightward-pointing arrow indicates in-phase coherence and leftward-pointing arrow indicates antiphase coherence. (b) A segment of real-time MAP and ${\mathrm{S}}_{\mathrm{ct}}{\mathrm{O}}_2$ data. (c) MRI brain image acquired 2 days after ECMO.