Fig. 7.

Cuprizone treatment (5 weeks) leads to a decrease in retinogeniculate network activity. a Representative example of traces obtained in the presence (red; iGluR blockade) or absence (black; baseline) of the glutamate receptor antagonists APV (NMDA receptor-selective) and DNQX (AMPA/kainate receptor-selective). Note that only the second peak of the traces is glutamate receptor inhibition-sensitive. b, c Representative example (b) and bar graph depicting the current amplitude (c) of traces obtained in the presence (red; GluN2B blockade) or absence (black; baseline) of Ro 25-6981, a selective blocker of NMDA receptors containing the GluN2B subunit. n = 5: cuprizone; n = 8: control. The bar graph depicts means ± SEMs. *p < 0.05, **p < 0.01, ***p < 0.001, not significant (ns) p ≥ 0.05 (unpaired two-tailed Student’s t test)