Fig. 6.

Schematic representation of the endocytosis and degradation or recycling of receptor tyrosine kinases in mock-infected (A) or infected (B) cells. In mock-infected cells, binding of the ligand results in dimerization and autophosphorylation of the receptor, recruitment and phosphorylation of Cbl, interaction with the adaptor protein CIN85 and endophilin, endocytosis, and either ultimate recycling or degradation of the receptor. In infected cells, ICP0, CIN85, and Cbl may form a complex that promotes the degradation of receptor tyrosine kinases in a ligand-independent fashion. In addition, ICP0 may preclude recycling of ligand-activated receptors.