Fig. 6.

In-vivo study of drug response using cells carrying ZNF423 WT (CRISPR-ZR75-1) or variant genotypes. a Tumors removed from the mice in each treatment group (eight mice) after 30 days of drug treatment. b Tumor volume measured every 3 days during treatment. Volume shown as mean ± SEM for eight mice, comparisons between WT and variant performed with two-tailed Student’s t test. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Ola olaparib, PBS phosphate-buffered saline, Tam tamoxifen, WT wild type