Table 2. Density of neurons in the brains of WT and GluR-B(N) mice.
| Brain region | Mice | Age, months | Density of neurons, Nv; mean/mm3 ± SEM | n |
|---|---|---|---|---|
| BLA | WT | 12 | 152,677 ± 1,570 | 5 |
| 24 | 144,000 ± 8,901 | 5 | ||
| GluR-B(N) | 12 | 105,299 ± 3,183*** | 6 | |
| 24 | 90,330 ± 5,938*** | 11 | ||
| VMH | WT | 12 | 302,496 ± 10,601 | 5 |
| 24 | 282,400 ± 16,118 | 5 | ||
| GluR-B(N) | 12 | 192,512 ± 3,791*** | 5 | |
| 24 | 177,192 ± 13,784*** | 10 | ||
| Purkinje cells | WT | 12 | 205,924 ± 3,052 | 9 |
| 24 | 199,930 ± 3,528 | 6 | ||
| GluR-B(N) | 12 | 202,491 ± 5,376 | 10 | |
| 24 | 199,052 ± 3,257 | 13 | ||
| CA3 | WT | 12 | 298,394 ± 5,625 | 9 |
| 24 | 307,307 ± 8,801 | 7 | ||
| GluR-B(N) | 12 | 299,081 ± 5,588 | 10 | |
| 24 | 283,623 ± 10,603 | 12 | ||
| CTX | WT | 12 | 120,120 ± 6,858 | 4 |
| 24 | 117,244 ± 3,076 | 8 | ||
| GluR-B(N) | 12 | 116,840 ± 6,901 | 4 | |
| 24 | 107,711 ± 3,175 | 6 | ||
| Mo5 | WT | 12 | 24,120 ± 3,031 | 4 |
| 24 | 28,667 ± 1,022 | 5 | ||
| GluR-B(N) | 12 | 25,200 ± 1,007 | 4 | |
| 24 | 28,053 ± 1,852 | 4 | ||
| LS | WT | 12 | 123,793 ± 6,228 | 4 |
| 24 | 121,685 ± 2,761 | 4 | ||
| GluR-B(N) | 12 | 106,371 ± 12,988 | 4 | |
| 24 | 109,862 ± 4,887 | 5 |
ANOVA revealed that densities of neurons (Nvs) in the BLA and VMH were lower in 12-and 24-month-old GluR-B(N) vs. age-matched WT mice [FBLA(1,23) = 61.40, P < 0.001; FVMH(1,21) = 55.95, P < 0.001]. ***, P < 0.001 vs. age-matched WT mice. BLA, basolateral amygdaloid nucleus; VMH, ventromedial hypothalamic nucleus; CA3, hippocampal subfield CA3; CTX, pyramidal cells in the motor cortex layer V; Mo5, motor trigeminal nucleus; LS, lateral septum dorsal nucleus.