Table 2.
Common side effects of different immunotherapies
| Targets | Medications | Side effects |
|---|---|---|
| CD20 | Rituximab | Most common side effect is mild to moderate infusion reactions. Rare cases of severe mucocutaneous reactions, HBV reactivation, and progressive multifocal leukoencephalopathy |
| Ofatumumab | Primarily grade 1 or 2 infusion reactions or infections | |
| CD19 | SAR3419 | Dose-limiting reversible severe vision changes associated with corneal changes |
| SGN-CD19A | Superficial microcystic keratopathy | |
| Blinatumomab | Fever, chills, and hypogammaglobulinemia are common. Serious side effects include CRS and neurotoxicity | |
| CD22 | Epratuzumab | Seizure, liver toxicity |
| INO | Liver toxicity, veno-occlusive disease in transplant patients | |
| CD52 | Alemtuzumab | Severe neutropenia, CMV viremia |