Table 2.
Top 10 most strongly associated Human MitoCarta genes with short-term PM10 exposure for women and men
| Gene symbol | Gene name | FC (95% CI) | P-value | Q-value |
|---|---|---|---|---|
| Women | ||||
| POLG | polymerase (DNA) gamma, catalytic subunit | 0.83 (0.78, 0.90) | 1.31E-05 | 0.01 |
| MRPL38 | mitochondrial ribosomal protein L38 | 0.83 (0.76, 0.90) | 1.08E-04 | 0.04 |
| MRPL16 | mitochondrial ribosomal protein L16 | 0.83 (0.77, 0.91) | 1.46E-04 | 0.04 |
| OGG1 | 8-oxoguanine DNA glycosylase | 0.81 (0.73, 0.89) | 1.48E-04 | 0.04 |
| ECHS1 | enoyl-CoA hydratase, short chain, 1, mitochondrial | 0.87 (0.81, 0.93) | 1.92E-04 | 0.04 |
| GTPBP3 | GTP binding protein 3 (mitochondrial) | 0.82 (0.74, 0.90) | 1.99E-04 | 0.04 |
| ECI2 | enoyl-CoA delta isomerase 2 | 0.84 (0.77, 0.92) | 2.86E-04 | 0.04 |
| ETHE1 | ETHE1, persulfide dioxygenase | 0.86 (0.79, 0.92) | 3.23E-04 | 0.04 |
| POLRMT | polymerase (RNA) mitochondrial | 0.86 (0.80, 0.93) | 4.91E-04 | 0.06 |
| BOLA1 | bolA family member 1 | 0.87 (0.81, 0.93) | 5.64E-04 | 0.06 |
| Men | ||||
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | 1.20 (1.08, 1.33) | 1.31E-03 | 0.97 |
| CKMT1A | creatine kinase, mitochondrial 1A | 1.30 (1.10, 1.53) | 4.09E-03 | 0.97 |
| PGS1 | phosphatidylglycerophosphate synthase 1 | 1.30 (1.10, 1.54) | 4.32E-03 | 0.97 |
| GNG5 | G protein subunit gamma 5 | 1.12 (1.04, 1.21) | 7.37E-03 | 0.97 |
| TMBIM4 | transmembrane BAX inhibitor motif containing 4 | 1.12 (1.03, 1.22) | 1.01E-02 | 0.97 |
| CHCHD6 | coiled-coil-helix-coiled-coil-helix domain containing 6 | 1.11 (1.03, 1.19) | 1.30E-02 | 0.97 |
| CHCHD8 | coiled-coil-helix-coiled-coil-helix domain containing 8 | 1.17 (1.04, 1.32) | 1.44E-02 | 0.97 |
| COX6A2 | cytochrome c oxidase subunit 6A2 | 1.26 (1.06, 1.50) | 1.46E-02 | 0.97 |
| RPL34 | ribosomal protein L34 | 0.83 (0.72, 0.96) | 1.49E-02 | 0.97 |
| DHRS7B | dehydrogenase/reductase 7B | 1.15 (1.03, 1.28) | 1.58E-02 | 0.97 |
FC fold change calculated for an increase in PM10 of 10 μg/m3