Fig. 1.

Alignment of partial adenovirus hexon sequences and hexon protein trimer structure. a Sequence alignment of 19 adenovirus hexon sequences containing HVRs 1-6. Protein sequences were obtained from GenBank and the alignment was performed using the MUSCLE algorithm. The color intensity indicates how highly an amino acid in a particular position is conserved amongst species. Highly conserved epitopes are highlighted in dark blue while variable epitopes are white or light blue. The HVRs 1-6 are highlighted by red bars and the cloned hexon fragments are highlighted by a blue bar. Hexon N- and C-terminal ends were omitted (for alignment of full-length hexon sequences see Additional file 1: Figure S1). b Graphical representation of the HAdV-C5 hexon protein trimer structure (PDB ID: 3TG7), side and top view. The HVRs 1-6 are highlighted in red and HVR 7 is highlighted in green