Fig. 3.

The effect of CNO-induced medial amygdala silencing on sexual receptivity in ovariectomized, estradiol and progesterone primed female mice. Sexual receptivity was measured by determining the lordosis quotient (total number of lordosis events/total number of mounts × 100; LQ) in bilaterally DREADD-infected (A) and non-infected (B) subjects that received mounts from a stud male. All data are expressed as the mean ± SEM. # p < 0.05 between test 1 and tests 2–5 tests in estrous females given the DREADD activating drug, CNO, over tests 1–5, + p < 0.05 between test 1 and tests 2–5 in estrous females given saline over tests 1–5, * p < 0.05 between treatment groups comparisons. The number females treated with CNO vs saline is shown in parentheses. Prior to test 6 (shaded column), the intraperitoneal injections of either saline or CNO were switched from the treatment that had prevailed previously over tests 1–5. Then, prior to test 7, estrous females again received the same treatments (CNO or saline) that had been administered over tests 1–5.