Table 2.

Genes Related to Carcinogenesis and a Summary of Their Physiologic Roles

Gene	Role
CCL14	Monocyte recruitment to lesion and infection sites. Appears to be a biomarker for endometriosis and endometriosis-associated ovarian cancer because it recruits components of the immune system due to its effects on tumor-acting chemokines.
SICA2	Monocyte recruitment to lesion and infection sites. Appears to be a biomarker for endometriosis and endometriosis-associated ovarian cancer because it recruits components of the immune system due to its effects on tumor-acting chemokines.
StAR	Regulates rapid increases in pregnolone synthesis stimulated by trophic hormones formed in the adrenal cortex.
SPINT1	Blocks the production of biologically-active HGF. HGF stimulates the interaction between tumoral cells, matrix adhesions, migration and angiogenesis.
Keratin 8	Involved in cell motility and cancer progression.
FoxM1B	Regulates expression of genes essential for DNA replication in the cell cycle and mitosis. Has been noted in several types of cancer.
FOLR1	Mediates the distribution of 5-methyltetrahydrofolate inside cells. A biomarker for ovarian cancer.
CRABP1	Retinoic-acid binding protein. Retinoic acid binding appears to play a role in cell proliferation.
Claudin-7	Claudins are involved in the formation of epithelial cell junctions. Kominsky et al reported a decreased expression of claudin-7 in invasive ductal carcinoma of the breast compared to normal breast tissue.
eEF1A2	Oncogene in ovarian cancer pathogenesis.
PTCH2	Participates in hedgehog signalling and modulates tumorigenesis in the presence of Ptch1 haploinsufficiency in medulloblastomas and other tumors.
PPP1R1AB	Protein phosphatase 1 inhibitor, required for cell migration and retraction.
XRCC5	Subunit of the ATP-dependent DNA helicase Ku heterodimer.
ARID1A	Part of the SWI/SNF family, which regulates transcription of certain genes by altering their chromatin structure.
RUNX3	Codes for a runt-related transcription factor, member of the runt domain family.