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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Kidney Int. 2017 Mar 16;92(2):365–376. doi: 10.1016/j.kint.2017.01.020

Figure 12. A) Dialysate concentration of recombinant human (rh) IL-6 after intravenous (IV) injection of rh IL-6.

Figure 12

Immediately after ischemic AKI, 2000 ng/mL (n=2; A and B) or 200 ng/mL (n=1; C) of recombinant human (h) IL-6 was administered intravenously and peritoneal dialysis was started. Peritoneal dialysis fluid (dialysate) was collected and exchanged every 15 minutes for 1 hour; thus, dialysate samples were analyzed at 15 min, 30 min, 45 min, and 60 min. Absolute values of rh IL-6 at each time point are shown in A–C. Data are reported relative to rh IL-6 level in the dialysate in the 15 min sample within the same animal in D. Comparisons were made via ANOVA with multiple comparisons using uncorrected Fischer’s LSD and the 15 min group as the comparator: # P=0.089; * P= 0.013; ** P = 0.003; n = 3. Since rh IL-6 is detected in the dialysate after IV injection, these data indicate that circulating IL-6 may be removed by peritoneal dialysis.