Low dose peritoneal dialysis (PD) or Sham PD was performed one hour after ischemic AKI (AKI) for 4 hours with peritoneal dialysate exchanges occurring every hour [i.e., 1 exchange per hour for four hours for a total of 4 exchanges]. A) pH was increased with LD PD and B) BUN was significantly reduced with low dose PD. There were no differences between Sham PD and Low dose PD in any of the other parameters measured, including C) Serum creatinine, D) ATN score, E) Hematocrit, F) Serum IL-6, G) Lung MPO activity, H) Lung CXCL1, I) Serum CXCL1, J) Serum TNF, K) Serum IL-1β, L) Serum IFN-γ, and M) Serum IL-10. (Analysis with unpaired t-test; n= 9–10; ***P<0.0001)