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. 2017 Jul 28;199(5):1596–1605. doi: 10.4049/jimmunol.1700473

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Copyright © 2017 by The American Association of Immunologists, Inc.

This article is distributed under The American Association of Immunologists, Inc., Reuse Terms and Conditions for Author Choice articles.

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FIGURE 2. — Supplementation of PBMC cultures with native vimentin induced proliferation of CD4 T cells from IPF patients. (A) Representative line graphs showing CFSE dilution in gated CD4 T cells from controls (Con.) and IPF patients. Dose dependence was evident in increasing vimentin concentrations from top to bottom. (B) Quantitation of aggregate CFSE assays in Con. (n = 10) and IPF (n = 15). Representative line graphs showing downregulation of CD4 T cell FOXP3 (C) and aggregate compilations of the same (D). Cultures in these studies were stimulated or not with vimentin (1 μg/ml). **p < 0.01.