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. Author manuscript; available in PMC: 2017 Aug 19.
Published in final edited form as: Vaccine. 2015 Oct 23;33(50):7051–7060. doi: 10.1016/j.vaccine.2015.09.112

Table 1.

Immunocompromised mouse strains used to study DENV.

Mouse strain Deficiency* Outcome References
AG129 IFNα/βR and IFNγR (129 background) Mortality DENV-2, DENV-3, DENV-4 [40][67][74]
AGB6 IFNα/βR and IFNγR Mortality DENV-2, DENV-4 [75]
A129 IFNα/βR (129 background) Mortality DENV-2 Survival DENV-4 [47] [75]
G129 IFNγR in (129 background) Survival DENV-2 [41]
IFNAR−/− IFNα/βR Mortality DENV-2 [43]
Mavs−/− MAVS Survival DENV-2, DENV-4 [44][75]
STAT1−/− STAT1 Mortality DENV-2 [49]
STAT2−/− STAT2 Survival DENV-2 [49]
STAT1−/−2−/− STAT1 and STAT2 Mortality DENV-2 [49]
STAT1−/−/AR STAT1 and IFNα/βR Mortality DENV-2 [49]
STAT1−/−/GR STAT1 and IFNγR Survival DENV-2 [49]
IRF3−/− IRF3 Survival DENV-2 [48]
IRF7−/− IRF7 Survival DENV-2 [48]
IRF3−/−7−/− IRF3 and IRF7 Survival DENV-2 [48]
HLAIIFNAR−/− HLA-A*0201/Kb, A*1101/Kb, A*0101, B*0702, or DRB1*0101 transgenics and IFNα/βR Not evaluated for mortality# [52]
LysM-Cre+/−IFNARfl/fl IFNα/βRonly in macrophages Morbidity, some mortalityDENV-2 [66]
CD11c-Cre+/−IFNARfl/fl IFNα/βRonly in dendritic cells Morbidity, some mortality DENV-2 [66]
LysM-Cre+/−CD11c-Cre+/−IFNARfl/fl IFNα/βRonly in macrophages and dendritic cells Mortality DENV-2 [66]
CD4-Cre+/−IFNARfl/fl IFNα/βRonly in CD4+ cells Survival DENV-2 [66]
*

All mouse strains backcrossed to C57BL/6 unless otherwise noted

#

HLA*IFNAR−/− transgenic mice were sublethally infected and sacrificed to study immune responses.