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. Author manuscript; available in PMC: 2017 Aug 19.
Published in final edited form as: Vaccine. 2015 Oct 23;33(50):7051–7060. doi: 10.1016/j.vaccine.2015.09.112

Table 3.

Viruses tested for acute, non-neurotropic lethality in immunocompromised mouse strains.

Serotype Virus Mouse Mouse Route Outcome Dose Reference
DENV-2 D2Y98P AG129 AG129 i.p. Mortality ≥106 PFU [59]
D2Y98P-PP1 AG129 AG129 s.c. Mortality ≥105 PFU [61]
AG129 AG129 s.c. Mortality ADE + 103 PFU [65]
D2S10 AG129 AG129 i.v. Mortality ≥107 PFU [40][55]
AG129 AG129 i.v. Mortality ADE + 105–106PFU [55]
IFNAR−/− IFNAR−/− i.v. Mortality (60%) 107 PFU [43]
IFNAR−/− IFNAR−/− i.v. Mortality ADE + 106–107 PFU [43]
AGB6 AGB6 i.p Mortality 106.4 PFU [75]
A129 A129 i.p Mortality 107.4 PFU [75]
Mavs−/− Mavs−/− i.p Survival 107.5 PFU [75]
E124/128-IC AG129 AG129 i.v. Mortality 1011.2 GE [42]
D220 IFNAR−/− IFNAR−/− i.v. Mortality (60%) 107 PFU [43]
IFNAR−/− IFNAR−/− i.v. Mortality ADE + 105–106PFU [43]
A129 A129 i.v. Mortality 107 PFU [43]
A129 A129 i.v. Mortality ADE + 105–106PFU [43]
S221 AG129 AG129 i.v. Mortality ≥109 GE [54], [49],[47]
AG129 AG129 i.v. Mortality ADE + 108.7 GE [54]
IFNAR−/− IFNAR−/− i.v. Mortality 1012GE [44]
A129 A129 i.v. Mortality 1012 GE [47]
STAT1−/− STAT1−/− i.v. Mortality 1012 GE [49]
STAT2−/− STAT2s−/− i.v. Survival ≤1012 GE [49]
STAT1−/−2−/− STAT1−/−2−/− i.v. Mortality 1010 GE [49]
STAT1−/−/AR STAT1−/−/AR i.v. Mortality 1010 GE [49]
STAT1−/−/GR STAT1−/−/GR i.v. Survival ≤1010 GE [49]
IRF3−/− IRF3−/− i.v. Survival ≤1012GE [48]
IRF7−/− IRF7−/− i.v. Survival ≤1012GE [48]
IRF3−/−7−/− IRF3−/−7−/− i.v. Survival ≤1012GE [48]
Mavs−/− Mavs−/− i.v. Survival ≤1012 GE [44]
D2S20 AG129 AG129 i.v. Mortality ≥109GE [45]
IFNAR−/− IFNAR−/− i.v. Mortality 1011 GE [45]
DENV-3 C0360/94 AG129 AG129 i.p. Mortality 107.5 PFU [67]
DENV-4 703–4 AG129 AG129 i.p. Mortality 107.3 PFU [74]
AG129 AG129 i.p. Mortality ADE + 106.3 PFU [74]
TVP-376 AG129 AG129 i.p. Mortality ≥107 PFU [75]
AGB6 AGB6 i.p. Mortality (50%/100%) 106.4 / 107.4 PFU [75]
A129 A129 i.p. Survival 107PFU [75]
Mavs−/− Mavs−/− i.p. Survival 107.5 PFU [75]
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Survival: 0–10% death; Mortality: 75–100% death unless otherwise stated.

*

Inoculum of virus required to achieve the outcome. (Approximately 5×104 GE / PFU [44]).

Abbreviations: intraperitoneal (i.p.), subcutaneous (s.c.), intravenous (i.v.)