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. Author manuscript; available in PMC: 2018 Jan 26.
Published in final edited form as: J Med Chem. 2017 Jan 5;60(2):580–593. doi: 10.1021/acs.jmedchem.6b01148

Figure 2. Functional efficacies measured by the β-arrestin recruitment assay.

Figure 2

The (R)-enantiomers ((R)-9, -4, -6) are antagonists, whereas the (S)-enantiomers ((S)-9, -4, -6) are partial agonists. Emax is the % of dopamine efficacy. NA, no activity. The efficacies of (S)-enantiomers are significantly different from their corresponding (R)-enantiomers; (S)-9 efficacy is significant different from (S)-4 or (S)-6 efficacy (in each case, P < 0.0001 using one-way ANOVA followed by post hoc Tukey test).