Table 3.
SNPs with highest association with Gram negative LOS*
| Chr | SNP | Location** | P value | Gene | Gene function |
|---|---|---|---|---|---|
| 2 | chr2:146369734 | 1.46E+08 | 1.13E-07 | Intergenic | |
| 8 | rs513793 | 20774064 | 5.82E-07 | Intergenic | |
| 2 | chr2:146358394 | 1.46E+08 | 8.84E-07 | Intergenic | |
| 2 | chr2:146356963 | 1.46E+08 | 8.85E-07 | Intergenic | |
| 7 | rs2237499 | 39740846 | 1.06E-06 | Intron RALA | Encodes protein belonging to Ras family of GTP binding proteins, implicated in filopodia formation for cell migration |
| 2 | rs58162439 | 1.46E+08 | 1.55E-06 | Intergenic | |
| 16 | rs59876150 | 86918734 | 1.99E-06 | Intergenic | |
| 7 | rs4730486 | 1.11E+08 | 3.10E-06 | Intron IMMP2L | Encodes protein important for function of mitochondrial inner membrane peptidase (IMP) complex |
| 7 | rs6950974 | 37075828 | 3.20E-06 | Intron RALA | |
| 7 | rs7811308 | 1.11E+08 | 3.92E-06 | Intron IMMP2L |
*
Top ten SNPs for each analysis listed; covariates in analysis: gestational age, SGA, eigenvalues for ancestry, surgery and Cesarean section; infants who died before 72 hours excluded from controls and LOS
**
Location in base pairs from p telomere