Table 4.
SNPs with highest association with fungal LOS*
| Chr | SNP | Location** | P value | Gene | Gene function |
|---|---|---|---|---|---|
| 18 | rs645505 | 10682720 | 6.35E-07 | Intron PIEZO2 | Encodes protein which functions as part of mechanically-activated cation channels, connecting mechanical forces to biological signals |
| 10 | rs11597285 | 8589813 | 7.36E-07 | Intergenic | |
| 10 | rs2031558 | 8589408 | 7.49E-07 | Intergenic | |
| 10 | rs11596835 | 8589969 | 7.53E-07 | Intergenic | |
| 10 | chr10:113662222 | 1.14E+08 | 1.28E-06 | Intergenic | |
| 10 | rs11593542 | 8600339 | 1.37E-06 | Intergenic | |
| 10 | rs1325884 | 8599820 | 1.43E-06 | Intergenic | |
| 12 | rs16913666 | 18134955 | 1.73E-06 | Intergenic | |
| 4 | rs17599816 | 47164556 | 1.85E-06 | Intron GABRB1 | Encodes gamma-aminobutyric acid (GABA) A receptor, beta 1 |
| 3 | rs12490944 | 50059651 | 1.90E-06 | Intron RBM6 | Encodes RNA binding motif protein 6 (previously implicated in various cancers) |
*
Top ten SNPs for each analysis listed; covariates in analysis: gestational age, SGA, eigenvalues for ancestry, surgery and Cesarean section; infants who died before 72 hours excluded from controls and LOS
**
Location in base pairs from p telomere