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. 2017 May 18;8(9):686–695. doi: 10.1007/s13238-017-0413-7

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Proteins in salivary exosomes of IBD and healthy groups. (A) Comparison of the numbers of proteins in healthy controls and IBD patients. (B) 8 proteins that only exist in IBD patients (both CD and CD). The most reasonable protein that may interact between oral cavity and colon intestine is PSMA7. (C) PSMA7’s function in the inflammation or cancer in the digestive systems had been reported by many studies. The speculated way shows the expression of PSMA7 is high in the salivary exosomes of IBD patients. IBD may influence the oral mucosal cells to secret exosomes, which may express the similar protein pattern of colon tissues