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. 2017 May 29;8(9):696–700. doi: 10.1007/s13238-017-0424-4

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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AlphaLISA assays detection of CSF α-syn in human patients. (A) Comparison of the oligomer α-syn between PD, MSA, and control patients. (B) Comparison of the total α-syn between PD, MSA, and control patients. (C) Comparison of the O/T ratio between PD, MSA, and control patients. (D) Receiver operating curves (ROC) for the levels of O/T in the patients tested CSF. All PD and control patients were concluded for ROC analysis, the area under curve (AUC) = 0.701. For Figure 2A–C, scatterplots representing individual sample values (means of 3 technical replicates). Each bar represents the mean value. PD = Parkinson’s disease, MSA = multiple system atrophy