Fig. 2.
Effects of non-selective purinergic receptor blockade on Up4A-induced relaxation. Shown are concentration responses to Up4A (10−9–10−5 M) in porcine coronary small arteries in the control vessels (normal, n = 13; metabolic derangement, n = 7) and in the presence of 10 μM non-selective P1 receptor antagonist 8PT (normal, n = 5; metabolic derangement, n = 6), in the presenc e of 10 μM non-selective P2 receptor antagonist PPADS (normal, n = 5; metabolic derangement, n = 7) as well as in the presence of combined 8PT and PPADS (normal, n = 6; metabolic derangement, n = 4). Values are mean ± SEM. *P < 0.05 vs. Control; †P < 0.05 vs. PPADS; ‡P < 0.05 vs. 8PT; §P < 0.05 effect of 8PT + PPADS in metabolic derangement differs from that in normal